教育经历

承担项目情况

1. 基于SWATH-MS和质谱成像技术的栀子厚朴汤治疗抑郁症的药效物质基础研究，国家自然科学基金青年基金，2017年，排名第一。
2. 基于连续可变窗口采集和质谱成像技术的栀子厚朴汤LC-HR-MS/MS分析方法研究与应用，吉林省科技厅自然科学基金，2021年，排名第一。
3. 基于连续可变窗口采集和质谱成像技术的北五味子治疗阿尔茨海默症的药效物质基础研究，吉林省教育厅项目，2019年，排名第一。
4. 基于血清药物化学与谱效表征的北五味子治疗阿尔茨海默症的药效物质基础研究，吉林省中医药管理局项目，2017年，排名第一。
5. 基于高分辨质谱技术的黄芪桂枝五物汤防治缺血性脑卒中的物质基础研究，吉林省中医药管理局项目，2021年，排名第一。
6. 当归芍药散防治阿尔茨海默症的药效物质基础研究，吉林省卫生健康委项目，2018年，排名第一。
7. 基于血清药物化学与谱效表征的当归芍药散抗阿尔茨海默病物质基础研究，吉林市科技局杰出青年项目，2016年，排名第一。
8. 药学类专业药物分析课程教学改革与实践，教育部产学合作协同育人项目，2021年，排名第一。
9. 互联网背景下融合思政教育的药物分析课程改革与实践，吉林医药学院校级重点教改课题，2021年，排名第一。
10. 栀子厚朴汤的质量控制与物质基础研究，国家级大学生创新创业项目，2019年，指导教师。

代表性著作

1. Heyun Zhu，Jiao Guan，Hui Zhang，Sheng Chang，LimingWang，Jianyi Shi，Bo Feng∗，Jingkai Gu∗. Simultaneous determination of ferulic acid, paeoniflorin, and albiflorin in rat plasma by ultra-high performance liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study of Danggui-Shaoyao-San. Journal of Separation Science., 2020, 43: 2053-2060. (IF: 3.645)
2. Heyun Zhu, Jiao Guan, Jianyi Shi, Xu Pan, Sheng Chang, Tianyi Zhang, Bo Feng∗, Jingkai Gu∗. Simultaneous determination of eight bioactive constituents of Zhi-Zi-Hou-Po decoction in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study. Journal of Separation Science, 2020, 43: 406-417. (IF: 3.645)
3. Heyun Zhu, Kaishun Bi, Fei Han, Jiao Guan, Xiaoshu Zhang, Xinjuan Mao, Longshan Zhao, Qing Li, Xiaohong Hou, Ran Yin∗. Identification of the absorbed components and metabolites ofZhi-Zi-Da-Huang decoction in rat plasma by ultra-high performanceliquid chromatography coupled with quadrupole-time-of-flight massspectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2015, 111:277-287. (IF: 3.935)
4. Heyun Zhu, Kaishun Bi, Fei Han, Jiao Guana, Zheng Tang, Kelin Chen,Longshan Zhao, Qing Li, Ran Yin∗, Xiaohong Hou∗. Simultaneous determination of two iridoid glycosides, twoanthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS: Application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats. Journal of Chromatography B, 2014, 960: 116–125. (IF: 3.205)
5. Heyun Zhu, Ran Yin∗, Fei Han, Jiao Guan, Xiaoshu Zhang, Xinjuan Mao, Longshan Zhao, Qing Li, Xiaohong Hou, Kaishun Bi∗. Characterization of chemical constituents in Zhi–Zi–Da–Huang decoction by ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Separation Science, 2014, 37: 3489-3496. (IF: 3.645)
6. Heyun Zhu, Xiurong Zhang∗, Jiao Guan, Baiji Cui, Longshan Zhao, Xu Zhao. Pharmacokinetics and tissue distribution study of schisandrin B in rats by ultra-fast liquid chromatography with tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2013, 78– 79: 136– 140. (IF: 3.935)
7. Jiao Guan1, Liming Wang1, Jia Jin, Sheng Chang, Xiao Xiao, Bo Feng∗, Heyun Zhu∗. Simultaneous determination of calycosin-7-O-β -D-glucoside,cinnamic acid, paeoniflorin and albiflorin in rat plasma byUHPLC-MS/MS and its application to a pharmacokinetic study ofHuangqi Guizhi Wuwu Decoction. Journal of Pharmaceutical and Biomedical Analysis, 2019, 170: 1–7. (IF: 3.935)
8. Jiao Guan, Xiurong Zhang∗, Bo Feng, Donghai Zhao, Tong Zhao, Sheng Chang, Liming Wang, Heyun Zhu∗. Simultaneous determination of ferulic acid and gastrodin of Tianshu Capsule in rat plasma by ultra-fast liquid chromatography with tandem mass spectrometry and its application to a comparative pharmacokinetic study in normal and migraine rats. Journal of Separation Sciemce, 2017, 40: 4120-4127. (IF: 3.645 )
9. Yuxuan Li #, Yue Cui#, Lele Li, Xiaoyin Lin, Xinxin Zhou, Heyun Zhu∗, Bo Feng∗. Ultra-high-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry method for quantifying polymer poloxamer 124 and its application to pharmacokinetic study.  Journal of Separation Sciemce, 2021, 44: 3822-3829. (IF: 3.645)
10. Yuxuan Li†, Yue Cui†, Lele Li, Xiaoyin Lin, Xinxin Zhou, Heyun Zhu∗, Bo Feng∗. A UHPLC-Q-TOF/MS method for the determination of poloxamer 124 and its application in a tissue distribution study in rats. Analytical Methods, 2021, 13:5516-5522. (IF: 2.896 )