教育经历

承担项目情况

1. 基于液质联用技术的防己黄芪汤血中移行成分与药代动力学研究，吉林市科技局，2016，排名第1。
2. 黄芪桂枝五物汤治疗脑梗塞的药效物质基础研究，吉林省中医药管理局，2018，排名第1。
3. 基于液相色谱-质谱联用技术的黄芪桂枝五物汤防治缺血性脑卒中的物质基础研究，吉林省教育厅，2021，排名第1。
4. 基于SWATH-MS和质谱成像技术的栀子厚朴汤治疗抑郁症药效物质基础研究，国家自然科学基金青年项目，2018，排名第2。
5. 基于连续可变窗口采集技术的泊洛沙姆聚合物LC-HR-MS/MS分析方法研究与应用，国家自然科学基金面上项目，2018，排名第5。

代表性著作

1. Jiao Guan1, Liming Wang1, Jia Jin, Sheng Chang, Xiao Xiao, Bo Feng∗, Heyun Zhu∗. Simultaneous determination of calycosin-7-O-β-D-glucoside, cinnamic acid, paeoniflorin and albiflorin in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study of Huangqi Guizhi Wuwu Decoction, Journal of Pharmaceutical and Biomedical Analysis, 2019, 170: 1–7. (IF: 3.935)
2. Jiao Guan, Xiurong Zhang*, Bo Feng, Donghai Zhao, Tong Zhao, Sheng Chang, Liming Wang, Heyun Zhu*. Simultaneous determination of ferulic acid and gastrodin of Tianshu Capsule in rat plasma by ultra-fast liquid chromatography with tandem mass spectrometry and its application to a comparative pharmacokinetic study in normal and migraine rats, Journal of Separation Science, 2017, 40:4120–4127. (IF: 3.645)
3. Jiao Guan, Qili Zhang, Rong Rong, Fei Han, Heyun Zhu, Yunli Zhao, Aihua Song*, Zhiguo Yu*. Metabolic profile of 2-(2-hydroxypropanamido) benzoic acid in rats by ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry, Journal of Chromatography B, 2015, 993-994: 60-68. (IF: 3.205)
4. Jiao Guan, Yunli Zhao, Heyun Zhu, Zhenzhen An, Yuming Yu, Ruijuan Li, Zhiguo Yu*. A rapid and sensitive UHPLC-MS/MS method for quantification of 2-(2-hydroxypropanamido) benzoic acid in rat plasma: Application to a pharmacokinetic study, Journal of Pharmaceutical and Biomedical Analysis, 2014, 95: 20-25. (IF: 3.935)
5. Xiurong Zhang#*, Jiao Guan#, Heyun Zhu, Tingting Niu. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study, Journal of Chromatography B, 2014, 971: 126-132. (IF: 3.205)
6. Jiao Guan†, Liming Wang†, Yuan Ji, Tianyi Zhang, Ye Sang, Sheng Chang, Bo Feng, Heyun Zhu*. UHPLC–MS/MS Method for Quantifying Fangchinoline, Tetrandrine and Calycosin-7-O-β-D-Glucoside of Fangji Huangqi Decoction in Rat Plasma and Its Application to a Pharmacokinetic Study. Journal of Chromatographic Science, 2021, 1-7. (IF: 1.617)
7. Jiao Guan#, Liqin Han#, Nianqiu Shi, Heyun Zhu*, Junmin Wang*. Development, in vitro biocompatibility, and antitumor efficacy of acetic acid-modified Cordyceps sinensis polysaccharide nanoparticle drug delivery system. Brazilian Journal of Pharmaceutical Sciences, 2020; 56: e18470. (IF: 1.321)